Sequence Detail

ID/Version

P70236 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Dual specificity mitogen-activated protein kinase kinase 6; Short=MAP kinase kinase 6; Short=MAPKK 6; EC=2.7.12.2;AltName: Full=MAPK/ERK kinase 6; Short=MEK 6;AltName: Full=SAPKK3;

Provider

SWISS-PROT

Sequence

Polypeptide 334 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Map2k6	mitogen-activated protein kinase kinase 6	45	103	3	16

Sequence references in MGI

J:36259 Cuenda A, et al., Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells. EMBO J. 1996 Aug 15;15(16):4156-64
J:84877 Brancho D, et al., Mechanism of p38 MAP kinase activation in vivo. Genes Dev. 2003 Aug 15;17(16):1969-78
J:85266 Tanaka N, et al., Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep. 2002 Aug;3(8):785-91
J:97767 Li Y, et al., Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons. J Biol Chem. 2005 Mar 18;280(11):10001-10
J:100093 Suzuki H, et al., Involvement of MKK6 in TCRalphabeta(int)CD69lo: a target population for apoptotic cell death in thymocytes. FASEB J. 2003 Aug;17(11):1538-40
J:104605 Zhang R, et al., Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):365-70
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89