Sequence Detail

ID/Version

P70196 Q6P9M0 Q8BLV2 (UniProt | EBI)

Last sequence update: 2010-02-09
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=TNF receptor-associated factor 6; EC=2.3.2.27;AltName: Full=E3 ubiquitin-protein ligase TRAF6;AltName: Full=RING-type E3 ubiquitin transferase TRAF6 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 530 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Traf6	TNF receptor-associated factor 6	189	101	3	20

Sequence references in MGI

J:36721 Ishida T, et al., Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J Biol Chem. 1996 Nov 15;271(46):28745-8
J:54467 Lomaga MA, et al., TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 1999 Apr 15;13(8):1015-24
J:77350 Naito A, et al., TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8766-71
J:77453 Naito A, et al., Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells. 1999 Jun;4(6):353-62
J:85808 Kobayashi T, et al., TRAF6 is a critical factor for dendritic cell maturation and development. Immunity. 2003 Sep;19(3):353-63
J:92728 Gohda J, et al., Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. J Immunol. 2004 Sep 1;173(5):2913-7
J:97344 Akiyama T, et al., Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science. 2005 Apr 8;308(5719):248-51
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:118130 Feng Y, et al., The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development. J Biol Chem. 2007 Jan 5;282(1):39-48
J:120542 Schwandner R, et al., Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. J Exp Med. 2000 Apr 3;191(7):1233-40
J:144594 Sanada T, et al., FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. J Biol Chem. 2008 Dec 5;283(49):33858-64
J:159274 Inoue J, et al., Characteristics and biological functions of TRAF6. Adv Exp Med Biol. 2007;597:72-9
J:169840 Saitoh T, et al., Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells. Immunity. 2011 Mar 25;34(3):352-63
J:196439 Chen BB, et al., A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Nat Immunol. 2013 May;14(5):470-9
J:240245 Wu DJ, et al., Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis. J Autoimmun. 2016 Sep;73:73-84
J:259118 Cardamone MD, et al., A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. Mol Cell. 2012 Apr 13;46(1):91-104
J:271376 Su X, et al., LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria. Nat Commun. 2014 Jul 16;5:4434