Sequence Detail

ID/Version

P70169 Q5SS41 Q6NXK3 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Double C2-like domain-containing protein beta; Short=Doc2-beta;

Provider

SWISS-PROT

Sequence

Polypeptide 412 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Doc2b	double C2, beta	41	100	3	8

Sequence references in MGI

J:39762 Kojima T, et al., Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta). J Biochem. 1996 Sep;120(3):671-6
J:137824 Friedrich R, et al., DOC2B acts as a calcium switch and enhances vesicle fusion. J Neurosci. 2008 Jul 2;28(27):6794-806
J:146942 Fukuda N, et al., DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes. Diabetes. 2009 Feb;58(2):377-84
J:158605 Groffen AJ, et al., Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science. 2010 Mar 26;327(5973):1614-8
J:161112 Ke B, et al., Doc2beta is a novel Munc18c-interacting partner and positive effector of syntaxin 4-mediated exocytosis. J Biol Chem. 2007 Jul 27;282(30):21786-97
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89