Sequence Detail

ID/Version

P68369 P05212 Q5XJF8 Q3TIW2 P05210 P02551 Q3TPJ1 Q3TGF0 Q3ULN1 (UniProt | EBI)

Last sequence update: 1986-07-21
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Tubulin alpha-1A chain; EC=3.6.5.- {ECO:0000250|UniProtKB:P68363};AltName: Full=Alpha-tubulin 1;AltName: Full=Alpha-tubulin isotype M-alpha-1;AltName: Full=Tubulin alpha-1 chain;Contains: RecName: Full=Detyrosinated tubulin alpha-1A

Provider

SWISS-PROT

Sequence

Polypeptide 451 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tuba1a	tubulin, alpha 1A	76	112	3	14

Sequence references in MGI

J:19085 Lewis SA, et al., Five mouse tubulin isotypes and their regulated expression during development. J Cell Biol. 1985 Sep;101(3):852-61
J:25928 Villasante A, et al., Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Mol Cell Biol. 1986 Jul;6(7):2409-19
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:112743 Peris L, et al., Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends. J Cell Biol. 2006 Sep 11;174(6):839-49
J:150280 Rogowski K, et al., Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell. 2009 Jun 12;137(6):1076-87
J:150408 Peris L, et al., Motor-dependent microtubule disassembly driven by tubulin tyrosination. J Cell Biol. 2009 Jun 29;185(7):1159-66
J:201638 Bosch Grau M, et al., Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. J Cell Biol. 2013 Aug 5;202(3):441-51
J:227641 Kerr JP, et al., Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle. Nat Commun. 2015;6:8526
J:241131 Janke C, et al., Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science. 2005 Jun 17;308(5729):1758-62
J:272424 Aillaud C, et al., Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. Science. 2017 Dec 15;358(6369):1448-1453
J:300009 Gadadhar S, et al., Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. Science. 2021 Jan 8;371(6525)