Sequence Detail

ID/Version

P63330 O88591 P13353 Q5SNY5 (UniProt | EBI)

Last sequence update: 2004-10-11
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; Short=PP2A-alpha; EC=3.1.3.16 {ECO:0000250|UniProtKB:P67775};

Provider

SWISS-PROT

Sequence

Polypeptide 309 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ppp2ca	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	77	110	5	25

Sequence references in MGI

J:53684 Hsu W, et al., Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. J Biol Chem. 1999 Feb 5;274(6):3439-45
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:130184 Lee J, et al., Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells. Nat Cell Biol. 2008 Jan;10(1):42-52
J:200438 Lechward K, et al., Interaction of nucleoredoxin with protein phosphatase 2A. FEBS Lett. 2006 Jun 26;580(15):3631-7
J:213891 Nawa M, et al., KCTD20, a relative of BTBD10, is a positive regulator of Akt. BMC Biochem. 2013;14:27
J:213903 Nawa M, et al., A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Cell Signal. 2008 Mar;20(3):493-505
J:245546 Hoffmeister M, et al., The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development. PLoS One. 2014;9(12):e116150
J:259480 Apostolidis SA, et al., Phosphatase PP2A is requisite for the function of regulatory T cells. Nat Immunol. 2016 May;17(5):556-64
J:266118 Crossthwaite AJ, et al., A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A. Mol Pharmacol. 2006 Feb;69(2):608-17
J:268220 Cianfanelli V, et al., AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. Nat Cell Biol. 2015 Jan;17(1):20-30
J:271695 Sonntag T, et al., Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. iScience. 2019 Jan 25;11:134-145
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:305800 Chou WC, et al., AIM2 in regulatory T cells restrains autoimmune diseases. Nature. 2021 Mar;591(7849):300-305
J:331917 Stutz A, et al., NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain. J Exp Med. 2017 Jun 5;214(6):1725-1736