Sequence Detail

ID/Version

P63328 B2RRX2 Q64135 P20652 Q3UCU1 P12816 (UniProt | EBI)

Last sequence update: 2004-10-11
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein phosphatase 3 catalytic subunit alpha {ECO:0000312|MGI:MGI:107164}; EC=3.1.3.16 {ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:7791792};AltName: Full=CAM-PRP catalytic subunit;AltName: Full=Calcineurin A alpha {ECO:0000303|

Provider

SWISS-PROT

Sequence

Polypeptide 521 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	158	110	4	27

Sequence references in MGI

J:9480 Kincaid RL, et al., Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin. Proc Natl Acad Sci U S A. 1988 Dec;85(23):8983-7
J:32280 Kincaid RL, et al., Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods. J Biol Chem. 1990 Jul 5;265(19):11312-9
J:54583 Zhuo M, et al., A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4650-5
J:57652 Becker W, et al., Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. J Biol Chem. 1994 Sep 9;269(36):22586-92
J:66484 Frey N, et al., Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14632-7
J:71750 Zhang BW, et al., T cell responses in calcineurin A alpha-deficient mice. J Exp Med. 1996 Feb 1;183(2):413-20
J:93625 Gooch JL, et al., Calcineurin A-alpha but not A-beta is required for normal kidney development and function. Am J Pathol. 2004 Nov;165(5):1755-65
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:103832 Sun L, et al., Calcineurin regulates bone formation by the osteoblast. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17130-5
J:110350 Gooch JL, et al., Loss of calcineurin Aalpha results in altered trafficking of AQP2 and in nephrogenic diabetes insipidus. J Cell Sci. 2006 Jun 15;119(Pt 12):2468-76
J:110822 Parsons SA, et al., Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice. Mol Cell Biol. 2003 Jun;23(12):4331-43
J:159586 Pena JA, et al., Loss of calcineurin Aalpha alters keratinocyte survival and differentiation. J Invest Dermatol. 2010 Jan;130(1):135-40
J:163320 Heineke J, et al., CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med. 2010 Aug;16(8):872-9
J:169854 Reddy RN, et al., Rescue of Calcineurin Aalpha(-/-) Mice Reveals a Novel Role for the alpha Isoform in the Salivary Gland. Am J Pathol. 2011 Apr;178(4):1605-13
J:174325 Kielbasa OM, et al., Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration. FASEB J. 2011 Jul;25(7):2276-86
J:257321 Li SJ, et al., Cooperative autoinhibition and multi-level activation mechanisms of calcineurin. Cell Res. 2016 Mar;26(3):336-49
J:259128 Genesca L, et al., Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. Biochem J. 2003 Sep 1;374(Pt 2):567-75
J:271695 Sonntag T, et al., Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. iScience. 2019 Jan 25;11:134-145
J:282598 Chaya T, et al., Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation. EMBO J. 2019 Dec 2;38(23):e101409
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:319680 Shinzawa M, et al., Catalytic subunits of the phosphatase calcineurin interact with NF-kappaB-inducing kinase (NIK) and attenuate NIK-dependent gene expression. Sci Rep. 2015 Jun 1;5:10758
J:320150 Sun L, et al., Evidence that calcineurin is required for the genesis of bone-resorbing osteoclasts. Am J Physiol Renal Physiol. 2007 Jan;292(1):F285-91