Sequence Detail

ID/Version

P63239 P21662 P22546 (UniProt | EBI)

Last sequence update: 2004-10-11
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Neuroendocrine convertase 1; Short=NEC 1; EC=3.4.21.93;AltName: Full=Furin homolog;AltName: Full=PC3;AltName: Full=Prohormone convertase 1;AltName: Full=Propeptide-processing protease;AltName: Full=Proprotein convertase 1;

Provider

SWISS-PROT

Sequence

Polypeptide 753 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pcsk1	proprotein convertase subtilisin/kexin type 1	41	112	3	13

Sequence references in MGI

J:10744 Seidah NG, et al., cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases [published erratum appears in DNA Cell Biol 1990 Dec;9(10):789]. DNA Cell Biol. 1990 Jul-Aug;9(6):415-24
J:11129 Seidah NG, et al., Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Mol Endocrinol. 1991 Jan;5(1):111-22
J:33115 Nakayama K, et al., Cloning and functional expression of a novel endoprotease involved in prohormone processing at dibasic sites. J Biochem. 1991 Jun;109(6):803-6
J:33624 Korner J, et al., Isolation and functional expression of a mammalian prohormone processing enzyme, murine prohormone convertase 1. Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6834-8