Sequence Detail

ID/Version

P63141 Q02010 P15386 B2RS05 Q8C8W4 (UniProt | EBI)

Last sequence update: 2004-09-13
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Potassium voltage-gated channel subfamily A member 2;AltName: Full=MK2 {ECO:0000303|PubMed:16141072};AltName: Full=Voltage-gated potassium channel subunit Kv1.2;

Provider

SWISS-PROT

Sequence

Polypeptide 499 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	63	101	3	14

Sequence references in MGI

J:10326 Chandy KG, et al., A family of three mouse potassium channel genes with intronless coding regions. Science. 1990 Feb 23;247(4945):973-5
J:19538 Wang H, et al., Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain. J Neurosci. 1994 Aug;14(8):4588-99
J:53425 Sobko A, et al., Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferation. J Neurosci. 1998 Dec 15;18(24):10398-408
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:130097 Douglas CL, et al., Sleep in Kcna2 knockout mice. BMC Biol. 2007;5:42
J:131735 Brew HM, et al., Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons. J Neurophysiol. 2007 Sep;98(3):1501-25
J:142445 Savvaki M, et al., Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes. Mol Cell Neurosci. 2008 Nov;39(3):478-90
J:149503 Ogawa Y, et al., Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2. J Neurosci. 2008 May 28;28(22):5731-9
J:166795 Xie G, et al., A new Kv1.2 channelopathy underlying cerebellar ataxia. J Biol Chem. 2010 Oct 15;285(42):32160-73
J:170639 Fulton S, et al., Contribution of Kv1.2 Voltage-gated Potassium Channel to D2 Autoreceptor Regulation of Axonal Dopamine Overflow. J Biol Chem. 2011 Mar 18;286(11):9360-72
J:184972 Zenker J, et al., Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus. J Neurosci. 2012 May 30;32(22):7493-8
J:197477 Kourrich S, et al., Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell. 2013 Jan 17;152(1-2):236-47
J:215893 Wang H, et al., Heteromultimeric K+ channels in terminal and juxtaparanodal regions of neurons. Nature. 1993 Sep 2;365(6441):75-9
J:217416 Gordon A, et al., Caspr and caspr2 are required for both radial and longitudinal organization of myelinated axons. J Neurosci. 2014 Nov 5;34(45):14820-6
J:226018 Kole MJ, et al., Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing. J Neurosci. 2015 Aug 12;35(32):11433-44
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89