Sequence Detail

ID/Version

P63115 Q9CW25 Q9JMH8 (UniProt | EBI)

Last sequence update: 2004-09-13
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Asc-type amino acid transporter 1; Short=Asc-1 {ECO:0000303|PubMed:25755256};AltName: Full=D-serine transporter;AltName: Full=Solute carrier family 7 member 10;

Provider

SWISS-PROT

Sequence

Polypeptide 530 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc7a10	solute carrier family 7 (cationic amino acid transporter, y+ system), member 10	28	99	4	5

Sequence references in MGI

J:61338 Fukasawa Y, et al., Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids. J Biol Chem. 2000 Mar 31;275(13):9690-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:222873 Safory H, et al., The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission. EMBO Rep. 2015 May;16(5):590-8
J:304984 Suwandhi L, et al., Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population. Nat Commun. 2021 Mar 11;12(1):1588
J:314162 Tatsumi K, et al., Olig2-astrocytes express neutral amino acid transporter SLC7A10 (Asc-1) in the adult brain. Mol Brain. 2021 Nov 8;14(1):163
J:331909 Ehmsen JT, et al., The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons. Sci Rep. 2016 Oct 19;6:35592