Sequence Detail

ID/Version

P63087 O09189 Q64679 P37139 O09186 (UniProt | EBI)

Last sequence update: 2004-09-13
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Short=PP-1G; EC=3.1.3.16 {ECO:0000250|UniProtKB:P36873};AltName: Full=Protein phosphatase 1C catalytic subunit;

Provider

SWISS-PROT

Sequence

Polypeptide 323 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ppp1cc	protein phosphatase 1 catalytic subunit gamma	95	101	3	48

Sequence references in MGI

J:30044 Ohkura H, et al., The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases. Cell. 1989 Jun 16;57(6):997-1007
J:40257 Okano K, et al., Genomic organization and functional analysis of the murine protein phosphatase 1c gamma (Ppp1cc) gene. Genomics. 1997 Oct 1;45(1):211-5
J:52211 Varmuza S, et al., Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1c gamma gene. Dev Biol. 1999 Jan 1;205(1):98-110
J:86710 Jousse C, et al., Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. J Cell Biol. 2003 Nov 24;163(4):767-75
J:92568 Hrabchak C, et al., Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis. J Biol Chem. 2004 Aug 27;279(35):37079-86
J:128272 Hrabchak C, et al., A testis specific isoform of endophilin B1, endophilin B1t, interacts specifically with protein phosphatase-1c gamma2 in mouse testis and is abnormally expressed in PP1c gamma null mice. Biochemistry. 2007 Apr 17;46(15):4635-44
J:149745 Popescu M, et al., Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1. J Biol Chem. 2009 May 15;284(20):13869-80
J:174435 Schmutz I, et al., Protein Phosphatase 1 (PP1) Is a Post-Translational Regulator of the Mammalian Circadian Clock. PLoS One. 2011;6(6):e21325
J:177139 Lee HM, et al., The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16451-6
J:178439 Wang R, et al., TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testis. Biol Cell. 2010 Mar;102(3):173-89
J:192200 Sinha N, et al., Significant expression levels of transgenic PPP1CC2 in testis and sperm are required to overcome the male infertility phenotype of Ppp1cc null mice. PLoS One. 2012;7(10):e47623
J:217282 Latreille M, et al., Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress. J Biol Chem. 2006 Sep 8;281(36):26633-44
J:244826 Matsuura M, et al., TMEM225: a possible protein phosphatase 1gamma2 (PP1gamma2) regulator localizes to the equatorial segment in mouse spermatozoa. Mol Reprod Dev. 2015 Feb;82(2):139-48
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89