Sequence Detail

ID/Version

P63011 P05713 Q3TSL4 (UniProt | EBI)

Last sequence update: 2004-08-31
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ras-related protein Rab-3A;

Provider

SWISS-PROT

Sequence

Polypeptide 220 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rab3a	RAB3A, member RAS oncogene family	116	102	4	9

Sequence references in MGI

J:13259 Baumert M, et al., Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes. Biochem J. 1993 Jul 1;293(Pt 1):157-63
J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
J:71887 Wang X, et al., Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal alpha -helix motifs. J Biol Chem. 2001 Aug 31;276(35):32480-8
J:81000 Fujimoto K, et al., Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis. J Biol Chem. 2002 Dec 27;277(52):50497-502
J:83108 Fukuda M, Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. J Biol Chem. 2003 Apr 25;278(17):15373-80
J:83162 Fukuda M, Slp4-a/Granuphilin-a Inhibits Dense-core Vesicle Exocytosis through Interaction with the GDP-bound Form of Rab27A in PC12 Cells. J Biol Chem. 2003 Apr 25;278(17):15390-6
J:90669 Matsumoto M, et al., Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8313-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:111329 Leenders AG, et al., Rab3a is involved in transport of synaptic vesicles to the active zone in mouse brain nerve terminals. Mol Biol Cell. 2001 Oct;12(10):3095-102
J:125105 Yang H, et al., Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. Genomics. 2007 Aug;90(2):249-60
J:163080 Yasuda T, et al., Rim2alpha determines docking and priming States in insulin granule exocytosis. Cell Metab. 2010 Aug 4;12(2):117-29
J:255588 Steger M, et al., Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. Elife. 2017 Nov 10;6:e31012
J:263424 Niwa S, et al., KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD. Nat Cell Biol. 2008 Nov;10(11):1269-79
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:292854 Xiao S, et al., Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels. Acta Neuropathol Commun. 2019 Oct 24;7(1):161