Sequence Detail

ID/Version

P62812 P18504 (UniProt | EBI)

Last sequence update: 2004-08-16
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Gamma-aminobutyric acid receptor subunit alpha-1;AltName: Full=GABA(A) receptor subunit alpha-1 {ECO:0000303|PubMed:16380713}; Short=GABAAR subunit alpha-1 {ECO:0000303|PubMed:27129275};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 455 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gabra1	gamma-aminobutyric acid type A receptor subunit alpha 1	76	107	3	28

Sequence references in MGI

J:2118 Wang JB, et al., The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development. J Mol Neurosci. 1992;3(4):177-84
J:11063 Keir WJ, et al., The cDNA sequence and chromosomal location of the murine GABAA alpha 1 receptor gene. Genomics. 1991 Feb;9(2):390-5
J:15086 Kato K, A collection of cDNA clones with specific expression patterns in mouse brain. Eur J Neurosci. 1990;2(8):704-11
J:105231 Gilbert SL, et al., Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Nat Genet. 2006 Feb;38(2):245-50
J:216966 Petriz A, et al., GABArho subunits confer a bicuculline-insensitive component to GFAP+ cells of cerebellum. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17522-7
J:232537 Swanson AM, et al., GABAAalpha1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection. Neuropsychopharmacology. 2015 Mar;40(4):1027-36
J:247418 Delto CF, et al., The LisH motif of muskelin is crucial for oligomerization and governs intracellular localization. Structure. 2015 Feb 03;23(2):364-73
J:281261 Brown LE, et al., gamma-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains. J Biol Chem. 2016 Jul 1;291(27):13926-42
J:281687 Han W, et al., Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions. Science. 2019 Oct 11;366(6462):246-250
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89