Sequence Detail

ID/Version

P61793 O88584 P56487 Q61130 A2AMJ2 P70420 (UniProt | EBI)

Last sequence update: 2004-06-07
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Lysophosphatidic acid receptor 1 {ECO:0000305}; Short=LPA receptor 1 {ECO:0000305}; Short=LPA-1 {ECO:0000303|PubMed:9600933, ECO:0000303|PubMed:9721207};AltName: Full=Lysophosphatidic acid receptor Edg-2 {ECO:0000303|PubMed:9

Provider

SWISS-PROT

Sequence

Polypeptide 364 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lpar1	lysophosphatidic acid receptor 1	106	142	3	51

Sequence references in MGI

J:36844 Hecht JH, et al., Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol. 1996 Nov;135(4):1071-83
J:37686 Macrae AD, et al., Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. Brain Res Mol Brain Res. 1996 Dec;42(2):245-54
J:49757 Contos JJ, et al., Complete cDNA sequence, genomic structure, and chromosomal localization of the LPA receptor gene, lpA1/vzg-1/Gpcr26. Genomics. 1998 Aug 1;51(3):364-78
J:65882 Contos JJ, et al., Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13384-9
J:78925 Contos JJ, et al., Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol Cell Biol. 2002 Oct;22(19):6921-9
J:91798 Inoue M, et al., Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat Med. 2004 Jul;10(7):712-8
J:130485 Tager AM, et al., The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med. 2008 Jan;14(1):45-54
J:136755 Shano S, et al., A lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation. Biochim Biophys Acta. 2008 May;1783(5):748-59
J:142304 Matas-Rico E, et al., Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus. Mol Cell Neurosci. 2008 Nov;39(3):342-55
J:174115 Estivill-Torrus G, et al., Absence of LPA1 signaling results in defective cortical development. Cereb Cortex. 2008 Apr;18(4):938-50
J:175298 Gennero I, et al., Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass. Bone. 2011 Sep;49(3):395-403
J:176269 Zhao J, et al., Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs. Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L547-56
J:204035 Lee SJ, et al., Distinct phospholipase C-beta isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure. Mol Cell Biol. 2013 May;33(10):2016-28
J:222685 Ishii I, et al., Functional comparisons of the lysophosphatidic acid receptors, LP(A1)/VZG-1/EDG-2, LP(A2)/EDG-4, and LP(A3)/EDG-7 in neuronal cell lines using a retrovirus expression system. Mol Pharmacol. 2000 Nov;58(5):895-902
J:222688 Fukushima N, et al., A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc Natl Acad Sci U S A. 1998 May 26;95(11):6151-6
J:244760 Santin LJ, et al., Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits. Genes Brain Behav. 2009 Nov;8(8):772-84
J:284688 Garcia-Diaz B, et al., Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex. Brain Struct Funct. 2015 Nov;220(6):3701-20
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89