Sequence Detail

ID/Version

P61092 Q06984 (UniProt | EBI)

Last sequence update: 2004-04-26
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase SIAH1A; EC=2.3.2.27 {ECO:0000269|PubMed:28546513};AltName: Full=RING-type E3 ubiquitin transferase SIAH1A {ECO:0000305};AltName: Full=Seven in absentia homolog 1a; Short=Siah-1a; Short=Siah

Provider

SWISS-PROT

Sequence

Polypeptide 282 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Siah1a	siah E3 ubiquitin protein ligase 1A	56	104	3	29

Sequence references in MGI

J:12699 Della NG, et al., Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina). Development. 1993 Apr;117(4):1333-43
J:75489 Dickins RA, et al., The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice. Mol Cell Biol. 2002 Apr;22(7):2294-303
J:82567 Park TJ, et al., Inhibition of ubiquitin ligase Siah-1A by disabled-1. Biochem Biophys Res Commun. 2003 Mar 21;302(4):671-8
J:126183 Frew IJ, et al., Normal p53 function in primary cells deficient for Siah genes. Mol Cell Biol. 2002 Dec;22(23):8155-64
J:159152 House CM, et al., Elucidation of the substrate binding site of Siah ubiquitin ligase. Structure. 2006 Apr;14(4):695-701
J:232292 Scortegagna M, et al., Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PLoS Genet. 2014 May;10(5):e1004348
J:319952 Ji L, et al., The SIAH E3 ubiquitin ligases promote Wnt/beta-catenin signaling through mediating Wnt-induced Axin degradation. Genes Dev. 2017 May 1;31(9):904-915