Sequence Detail

ID/Version

P60487 (UniProt | EBI)

Last sequence update: 2004-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Chronophin {ECO:0000303|PubMed:24338473}; EC=3.1.3.16 {ECO:0000250|UniProtKB:Q3ZBF9}; EC=3.1.3.74 {ECO:0000269|PubMed:24338473, ECO:0000269|PubMed:24338687, ECO:0000269|PubMed:25783190};AltName: Full=Pyridoxal 5'-phosphate ph

Provider

SWISS-PROT

Sequence

Polypeptide 292 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pdxp	pyridoxal (pyridoxine, vitamin B6) phosphatase	87	99	3	8

Sequence references in MGI

J:87177 Jang YM, et al., Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution. J Biol Chem. 2003 Dec 12;278(50):50040-6
J:205593 Kestler C, et al., Chronophin dimerization is required for proper positioning of its substrate specificity loop. J Biol Chem. 2014 Jan 31;289(5):3094-103
J:205594 Seifried A, et al., Evolutionary and Structural Analyses of Mammalian Haloacid Dehalogenase-type Phosphatases AUM and Chronophin Provide Insight into the Basis of Their Different Substrate Specificities. J Biol Chem. 2014 Feb 7;289(6):3416-31
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:304580 Knobloch G, et al., Synthesis of hydrolysis-resistant pyridoxal 5'-phosphate analogs and their biochemical and X-ray crystallographic characterization with the pyridoxal phosphatase chronophin. Bioorg Med Chem. 2015 Jun 15;23(12):2819-27