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Sequence Detail
ID/Version
P60202 P04400 P06905 Q9WUS9 (UniProt | EBI) Last sequence update: 2007-01-23
Last annotation update: 2019-09-18
Sequence
description
from provider
RecName: Full=Myelin proteolipid protein; Short=PLP;AltName: Full=Lipophilin;
Provider SWISS-PROT
Sequence
Polypeptide 277 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Plp1 proteolipid protein (myelin) 1 34 42 8 25
Sequence references in MGI J:2126 Schneider A, et al., Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene. Nature. 1992 Aug 27;358(6389):758-61
J:8514 Nave KA, et al., Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing. Proc Natl Acad Sci U S A. 1986 Dec;83(23):9264-8
J:9096 Ikenaka K, et al., Myelin proteolipid protein gene structure and its regulation of expression in normal and jimpy mutant mice. J Mol Biol. 1988 Feb 20;199(4):587-96
J:20245 Hudson LD, et al., Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1454-8
J:26979 Macklin WB, et al., Structure and expression of the mouse myelin proteolipid protein gene. J Neurosci Res. 1987;18(3):383-94
J:28225 Sorg BA, et al., Developmental expression of the myelin proteolipid protein and basic protein mRNAs in normal and dysmyelinating mutant mice. J Neurochem. 1987 Oct;49(4):1146-54
J:42979 Macklin WB, et al., An AG----GG transition at a splice site in the myelin proteolipid protein gene in jimpy mice results in the removal of an exon. FEBS Lett. 1987 Nov 2;223(2):417-21
J:42980 Gencic S, et al., Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice. J Neurosci. 1990 Jan;10(1):117-24
J:145263 Werner HB, et al., Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci. 2007 Jul 18;27(29):7717-30

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory