Sequence Detail

ID/Version

P59158 (UniProt | EBI)

Last sequence update: 2002-12-13
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Solute carrier family 12 member 3;AltName: Full=Na-Cl symporter;AltName: Full=Thiazide-sensitive sodium-chloride cotransporter {ECO:0000303|PubMed:15068971};

Provider

SWISS-PROT

Sequence

Polypeptide 1002 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc12a3	solute carrier family 12, member 3	57	121	3	13

Sequence references in MGI

J:129716 Yang SS, et al., Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 2007 May;5(5):331-44
J:152915 Ohta A, et al., Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet. 2009 Oct 15;18(20):3978-86
J:224865 Wang J, et al., Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med. 2015 Jul;21(7):820-6
J:284463 Frische S, et al., H(+)-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney. Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F429-F444
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:331463 Sabath E, et al., Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease. Am J Physiol Renal Physiol. 2004 Aug;287(2):F195-203
J:336073 Li Z, et al., R158Q and G212S, novel pathogenic compound heterozygous variants in SLC12A3 of Gitelman syndrome. Front Med. 2022 Dec;16(6):932-945