Sequence Detail

ID/Version

P58801 (UniProt | EBI)

Last sequence update: 2002-05-02
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Receptor-interacting serine/threonine-protein kinase 2; EC=2.7.11.1 {ECO:0000269|PubMed:19473975};AltName: Full=Receptor-interacting protein 2 {ECO:0000303|PubMed:19473975};AltName: Full=Tyrosine-protein kinase RIPK2; EC=2.7.

Provider

SWISS-PROT

Sequence

Polypeptide 539 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ripk2	receptor (TNFRSF)-interacting serine-threonine kinase 2	172	96	3	11

Sequence references in MGI

J:75401 Chin AI, et al., Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature. 2002 Mar 14;416(6877):190-4
J:117799 Hsu YM, et al., The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol. 2007 Feb;8(2):198-205
J:143980 Park JH, et al., RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J Immunol. 2007 Feb 15;178(4):2380-6
J:175412 Magalhaes JG, et al., Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands. Eur J Immunol. 2011 May;41(5):1445-55
J:208236 Yang S, et al., Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis. Nat Immunol. 2013 Sep;14(9):927-36
J:267514 Panda S, et al., The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex. Nat Commun. 2018 Nov 7;9(1):4654
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:335665 Yang Y, et al., NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2. J Biol Chem. 2007 Dec 14;282(50):36223-9
J:335666 Nembrini C, et al., The kinase activity of Rip2 determines its stability and consequently Nod1- and Nod2-mediated immune responses. J Biol Chem. 2009 Jul 17;284(29):19183-8