Sequence Detail

ID/Version

P58681 Q923I1 (UniProt | EBI)

Last sequence update: 2002-01-31
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Toll-like receptor 7;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1050 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tlr7	toll-like receptor 7	91	106	3	28

Sequence references in MGI

J:90024 Diebold SS, et al., Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science. 2004 Mar 5;303(5663):1529-31
J:132643 Kim YM, et al., UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature. 2008 Mar 13;452(7184):234-8
J:161113 Brinkmann MM, et al., The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol. 2007 Apr 23;177(2):265-75
J:224870 Heinz LX, et al., The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell Rep. 2015 Jun 30;11(12):1919-28
J:240588 Ewald SE, et al., Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. J Exp Med. 2011 Apr 11;208(4):643-51
J:324448 Brown GJ, et al., TLR7 gain-of-function genetic variation causes human lupus. Nature. 2022;605(7909):349-356