Sequence Detail

ID/Version

P58043 (UniProt | EBI)

Last sequence update: 2001-04-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Sestrin-2 {ECO:0000305}; EC=1.11.1.- {ECO:0000250|UniProtKB:P58004};

Provider

SWISS-PROT

Sequence

Polypeptide 480 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sesn2	sestrin 2	80	101	3	40

Sequence references in MGI

J:139563 Budanov AV, et al., p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell. 2008 Aug 8;134(3):451-60
J:189021 Lee JH, et al., Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 5;16(3):311-21
J:195093 Bae SH, et al., Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab. 2013 Jan 8;17(1):73-84
J:213953 Ro SH, et al., Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J. 2014 Sep;281(17):3816-27
J:214946 Peng M, et al., Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell. 2014 Sep 25;159(1):122-33
J:224583 Park HW, et al., Hepatoprotective role of Sestrin2 against chronic ER stress. Nat Commun. 2014;5:4233
J:232620 Tao R, et al., Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling. Diabetes. 2015 Apr;64(4):1211-23