Sequence Detail

ID/Version

P56726 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein smoothened;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 793 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Smo	smoothened, frizzled class receptor	182	142	3	20

Sequence references in MGI

J:41023 Akiyama H, et al., Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5. Biochem Biophys Res Commun. 1997 Jun 9;235(1):142-7
J:102118 Corbit KC, et al., Vertebrate Smoothened functions at the primary cilium. Nature. 2005 Oct 13;437(7061):1018-21
J:177990 Seo S, et al., A Novel Protein LZTFL1 Regulates Ciliary Trafficking of the BBSome and Smoothened. PLoS Genet. 2011 Nov;7(11):e1002358
J:218232 Chong YC, et al., Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5. Genes Dev. 2015 Feb 1;29(3):262-76
J:259132 Evron T, et al., Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling. J Biol Chem. 2011 Aug 5;286(31):27676-86
J:340660 Nedelcu D, et al., Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat Chem Biol. 2013 Sep;9(9):557-64
J:341399 Nachtergaele S, et al., Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife. 2013 Oct 29;2:e01340
J:341400 Arveseth CD, et al., Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits. PLoS Biol. 2021 Apr;19(4):e3001191