Sequence Detail

ID/Version

P55284 O35542 (UniProt | EBI)

Last sequence update: 2003-09-09
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cadherin-5 {ECO:0000312|MGI:MGI:105057};AltName: Full=Vascular endothelial cadherin {ECO:0000303|PubMed:8555485}; Short=VE-cadherin {ECO:0000303|PubMed:12234928};AltName: CD_antigen=CD144;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 784 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cdh5	cadherin 5	123	182	3	26

Sequence references in MGI

J:30623 Breier G, et al., Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. (Errata: vol. 88(3):1129-33). Blood. 1996 Jan 15;87(2):630-41
J:51731 Matsuyoshi N, et al., In vivo evidence of the critical role of cadherin-5 in murine vascular integrity. Proc Assoc Am Physicians. 1997 Jul;109(4):362-71
J:152727 Kanemura H, et al., Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1. Biochem Biophys Res Commun. 2009 Oct 2;387(4):754-9
J:156243 Nawroth R, et al., VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J. 2002 Sep 16;21(18):4885-95
J:170050 Lampugnani MG, et al., CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci. 2010 Apr 1;123(Pt 7):1073-80
J:184007 Costa G, et al., SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development. Development. 2012 May;139(9):1587-98
J:226656 Hultin S, et al., AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion. Nat Commun. 2014;5:3743
J:262023 Morooka N, et al., Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling. Circ Res. 2017 Apr 14;120(8):1276-1288
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:342706 Malinova TS, et al., A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis. Nat Commun. 2021 May 10;12(1):2610