Sequence Detail

ID/Version

P55144 Q60752 P70285 O09070 Q6NZM6 O09080 Q62482 Q62484 Q78E85 Q78E87 Q62483 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tyrosine-protein kinase receptor TYRO3; EC=2.7.10.1;AltName: Full=Etk2/tyro3;AltName: Full=TK19-2;AltName: Full=Tyrosine-protein kinase DTK;AltName: Full=Tyrosine-protein kinase RSE;AltName: Full=Tyrosine-protein kinase TIF;Flags: Pr

Provider

SWISS-PROT

Sequence

Polypeptide 880 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tyro3	TYRO3 protein tyrosine kinase 3	75	108	3	49

Sequence references in MGI

J:16985 Fujimoto J, et al., brt, a mouse gene encoding a novel receptor-type protein-tyrosine kinase, is preferentially expressed in the brain. Oncogene. 1994 Mar;9(3):693-8
J:17035 Ohashi K, et al., Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain. Oncogene. 1994 Mar;9(3):699-705
J:19923 Lai C, et al., Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase. Oncogene. 1994 Sep;9(9):2567-78
J:22047 Crosier PS, et al., Isolation of a receptor tyrosine kinase (DTK) from embryonic stem cells: structure, genetic mapping and analysis of expression. Growth Factors. 1994;11(2):125-36
J:22672 Schulz NT, et al., Isolation and expression analysis of tyro3, a murine growth factor receptor tyrosine kinase preferentially expressed in adult brain. Brain Res Mol Brain Res. 1995 Feb;28(2):273-80
J:31556 Biesecker LG, et al., Identification of alternative exons, including a novel exon, in the tyrosine kinase receptor gene Etk2/tyro3 that explain differences in 5' cDNA sequences. Oncogene. 1995 Jun 1;10(11):2239-42
J:31909 Mark MR, et al., rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. J Biol Chem. 1994 Apr 8;269(14):10720-8
J:35581 Sasaki M, et al., Structure and expression of a murine homologue of sky receptor tyrosine kinase gene. J Biochem. 1996 Aug;120(2):264-70
J:54681 Lu Q, et al., Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature. 1999 Apr 22;398(6729):723-8
J:95952 Angelillo-Scherrer A, et al., Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest. 2005 Feb;115(2):237-46
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:167178 Caberoy NB, et al., Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis. EMBO J. 2010 Dec 1;29(23):3898-910
J:182379 Zhong Z, et al., Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci. 2010 Nov 17;30(46):15521-34
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89