Sequence Detail

ID/Version

P55098 O35467 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Peroxisome biogenesis factor 2 {ECO:0000305}; EC=2.3.2.27 {ECO:0000250|UniProtKB:P32800}; EC=2.3.2.36 {ECO:0000250|UniProtKB:P32800};AltName: Full=Peroxin-2 {ECO:0000305};AltName: Full=Peroxisomal membrane protein 3;AltName:

Provider

SWISS-PROT

Sequence

Polypeptide 305 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pex2	peroxisomal biogenesis factor 2	34	103	3	3

Sequence references in MGI

J:35228 Wilson GN, et al., Structure and expression of mammalian peroxisome assembly factor-1 (PMP35) genes. Biochem Med Metab Biol. 1994 Apr;51(2):140-8
J:44975 Faust PL, et al., Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder. J Cell Biol. 1997 Dec 1;139(5):1293-305
J:83644 Faust PL, Abnormal cerebellar histogenesis in PEX2 Zellweger mice reflects multiple neuronal defects induced by peroxisome deficiency. J Comp Neurol. 2003 Jun 30;461(3):394-413
J:87591 Kovacs WJ, et al., Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model. Mol Cell Biol. 2004 Jan;24(1):1-13
J:148375 Kovacs WJ, et al., Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress. J Biol Chem. 2009 Mar 13;284(11):7232-45
J:185169 Kovacs WJ, et al., Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice. Biochim Biophys Acta. 2012 Jun;1821(6):895-907
J:341889 Abe Y, et al., Peroxisome Deficiency Impairs BDNF Signaling and Memory. Front Cell Dev Biol. 2020;8:567017