Sequence Detail

ID/Version

P55088 Q8VHE4 Q4FJP1 Q9EQI3 Q8VHE5 Q61132 Q61131 P97818 (UniProt | EBI)

Last sequence update: 2004-05-10
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Aquaporin-4; Short=AQP-4;AltName: Full=Mercurial-insensitive water channel {ECO:0000303|PubMed:8660998}; Short=MIWC {ECO:0000303|PubMed:8660998};AltName: Full=WCH4;

Provider

SWISS-PROT

Sequence

Polypeptide 323 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Aqp4	aquaporin 4	72	128	3	21

Sequence references in MGI

J:32891 Ma T, et al., Gene structure, cDNA cloning, and expression of a mouse mercurial-insensitive water channel. Genomics. 1996 May 1;33(3):382-8
J:39832 Turtzo LC, et al., Cloning and chromosomal localization of mouse aquaporin 4: exclusion of a candidate mutant phenotype, ataxia. Genomics. 1997 Apr 15;41(2):267-70
J:42704 Ma T, et al., Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest. 1997 Sep 1;100(5):957-62
J:63987 Wang KS, et al., Gastric acid secretion in aquaporin-4 knockout mice. Am J Physiol Gastrointest Liver Physiol. 2000 Aug;279(2):G448-53
J:71154 Li J, et al., Impaired hearing in mice lacking aquaporin-4 water channels. J Biol Chem. 2001 Aug 17;276(33):31233-7
J:109463 McDill BW, et al., Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation. Proc Natl Acad Sci U S A. 2006 May 2;103(18):6952-7
J:187150 Iliff JJ, et al., A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid beta. Sci Transl Med. 2012 Aug 15;4(147):147ra111
J:260928 Vindedal GF, et al., Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation. Mol Cell Neurosci. 2016 Dec;77:47-52
J:273546 Gunnarson E, et al., Identification of a molecular target for glutamate regulation of astrocyte water permeability. Glia. 2008 Apr 15;56(6):587-96
J:273559 Rosito S, et al., Supramolecular aggregation of aquaporin-4 is different in muscle and brain: correlation with tissue susceptibility in neuromyelitis optica. J Cell Mol Med. 2018 Feb;22(2):1236-1246
J:277304 Mestre H, et al., Aquaporin-4-dependent glymphatic solute transport in the rodent brain. Elife. 2018 Dec 18;7:e40070
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:298774 Ohene Y, et al., Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study. Neuroimage. 2019 Mar;188:515-523