Sequence Detail

ID/Version

P55012 E9PYU3 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2026-01-28

Sequence description from provider

RecName: Full=Solute carrier family 12 member 2;AltName: Full=Basolateral Na-K-Cl symporter;AltName: Full=Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 {ECO:0000303|PubMed:7929272}; Short=BSC2;AltName: Full=Na-K-2Cl cotransporte

Provider

SWISS-PROT

Sequence

Polypeptide 1205 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc12a2	solute carrier family 12, member 2	80	117	4	21

Sequence references in MGI

J:21042 Delpire E, et al., Molecular cloning and chromosome localization of a putative basolateral Na(+)-K(+)-2Cl- cotransporter from mouse inner medullary collecting duct (mIMCD-3) cells. J Biol Chem. 1994 Oct 14;269(41):25677-83
J:139340 Piechotta K, et al., Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase. J Biol Chem. 2003 Dec 26;278(52):52848-56
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:177443 Lin SH, et al., Impaired phosphorylation of Na+-K+-2Cl- cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17538-43
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89