Sequence Detail

ID/Version

P54841 Q3UPT9 Q3U3C8 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transcription factor MafB; Short=Maf-B;AltName: Full=Kreisler;AltName: Full=Segmentation protein Kr;AltName: Full=Transcription factor Maf-1;AltName: Full=V-maf musculoaponeurotic fibrosarcoma oncogene homolog B;

Provider

SWISS-PROT

Sequence

Polypeptide 323 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mafb	MAF bZIP transcription factor B	62	175	3	23

Sequence references in MGI

J:22020 Cordes SP, et al., The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor. Cell. 1994 Dec 16;79(6):1025-34
J:56095 Kawauchi S, et al., Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem. 1999 Jul 2;274(27):19254-60
J:60301 Huang K, et al., Molecular cloning and functional characterization of the mouse mafB gene. Gene. 2000 Jan 25;242(1-2):419-26
J:85746 Blanchi B, et al., MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth. Nat Neurosci. 2003 Oct;6(10):1091-100
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:106430 Artner I, et al., MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Diabetes. 2006 Feb;55(2):297-304
J:111415 Moriguchi T, et al., MafB is essential for renal development and F4/80 expression in macrophages. Mol Cell Biol. 2006 Aug;26(15):5715-27
J:112301 Aziz A, et al., Development of macrophages with altered actin organization in the absence of MafB. Mol Cell Biol. 2006 Sep;26(18):6808-18
J:120055 Artner I, et al., MafB is required for islet beta cell maturation. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3853-8
J:132598 Nishimura W, et al., Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol. 2008 Feb 15;314(2):443-56
J:132603 Saul SM, et al., Math5 expression and function in the central auditory system. Mol Cell Neurosci. 2008 Jan;37(1):153-69
J:150006 Smink JJ, et al., Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB. EMBO J. 2009 Jun 17;28(12):1769-81
J:237642 Park JG, et al., Loss of MAFB Function in Humans and Mice Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects. Am J Hum Genet. 2016 Jun 02;98(6):1220-7
J:285221 Manzanares M, et al., Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain. EMBO J. 2002 Feb 1;21(3):365-76