Sequence Detail

ID/Version

P54763 A3KG02 Q9QVY4 A3KG01 A3KG90 Q6GTQ7 A3KG00 Q62213 A3KG89 Q6P5F1 (UniProt | EBI)

Last sequence update: 2015-10-14
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Ephrin type-B receptor 2 {ECO:0000305}; EC=2.7.10.1;AltName: Full=Neural kinase;AltName: Full=Nuk receptor tyrosine kinase;AltName: Full=Tyrosine-protein kinase receptor EPH-3;AltName: Full=Tyrosine-protein kinase receptor SEK-3;Cont

Provider

SWISS-PROT

Sequence

Polypeptide 986 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ephb2	Eph receptor B2	133	149	4	54

Sequence references in MGI

J:19646 Becker N, et al., Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech Dev. 1994 Jul;47(1):3-17
J:31706 Henkemeyer M, et al., Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis. Oncogene. 1994 Apr;9(4):1001-14
J:34200 Henkemeyer M, et al., Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell. 1996 Jul 12;86(1):35-46
J:37095 Orioli D, et al., Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J. 1996 15;15(22):6035-49
J:51893 Torres R, et al., PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron. 1998 Dec;21(6):1453-63
J:53085 Adams RH, et al., Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 1999 Feb 1;13(3):295-306
J:58260 Dodelet VC, et al., A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. J Biol Chem. 1999 Nov 5;274(45):31941-6
J:60835 Imondi R, et al., Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons. Development. 2000 Apr;127(7):1397-410
J:62565 Cowan CA, et al., EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron. 2000 May;26(2):417-30
J:73356 Himanen JP, et al., Crystal structure of an Eph receptor-ephrin complex. Nature. 2001 Dec 20-27;414(6866):933-8
J:87071 Henkemeyer M, et al., Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus. J Cell Biol. 2003 Dec 22;163(6):1313-26
J:91491 Dravis C, et al., Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development. Dev Biol. 2004 Jul 15;271(2):272-90
J:116249 Himanen JP, et al., Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nat Neurosci. 2004 May;7(5):501-9
J:122772 Litterst C, et al., Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. J Biol Chem. 2007 Jun 1;282(22):16155-63
J:167914 Margolis SS, et al., EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Cell. 2010 Oct 29;143(3):442-55
J:241039 Alonso-Martin S, et al., Gene Expression Profiling of Muscle Stem Cells Identifies Novel Regulators of Postnatal Myogenesis. Front Cell Dev Biol. 2016;4:58
J:266463 Okumura F, et al., Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2. Mol Biol Cell. 2017 Nov 15;28(24):3532-3541
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89