Sequence Detail

ID/Version

P54265 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Myotonin-protein kinase; Short=MT-PK; EC=2.7.11.1;AltName: Full=DM-kinase; Short=DMK;AltName: Full=DMPK;AltName: Full=Myotonic dystrophy protein kinase; Short=MDPK;

Provider

SWISS-PROT

Sequence

Polypeptide 631 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dmpk	dystrophia myotonica-protein kinase	40	107	2	8

Sequence references in MGI

J:12705 Jansen G, et al., Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs. Nat Genet. 1992 Jul;1(4):261-6
J:17642 Mahadevan MS, et al., Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene. Hum Mol Genet. 1993 Mar;2(3):299-304
J:23408 Jansen G, et al., No imprinting involved in the expression of DM-kinase mRNAs in mouse and human tissues. Hum Mol Genet. 1993 Aug;2(8):1221-7
J:33714 Reddy S, et al., Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy [see comments]. Nat Genet. 1996 Jul;13(3):325-35
J:43052 Benders AA, et al., Myotonic dystrophy protein kinase is involved in the modulation of the Ca2+ homeostasis in skeletal muscle cells. J Clin Invest. 1997 Sep 15;100(6):1440-7
J:60940 Groenen PJ, et al., Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties. Hum Mol Genet. 2000 Mar 1;9(4):605-16
J:96089 van Herpen RE, et al., Divergent mitochondrial and endoplasmic reticulum association of DMPK splice isoforms depends on unique sequence arrangements in tail anchors. Mol Cell Biol. 2005 Feb;25(4):1402-14
J:97257 Kaliman P, et al., Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum. J Biol Chem. 2005 Mar 4;280(9):8016-21
J:103029 Schulz PE, et al., A role for myotonic dystrophy protein kinase in synaptic plasticity. J Neurophysiol. 2003 Mar;89(3):1177-86
J:138797 Harmon EB, et al., Myotonic dystrophy protein kinase is expressed in embryonic myocytes and is required for myotube formation. Dev Dyn. 2008 Sep;237(9):2353-66
J:178475 Harmon EB, et al., Myotonic dystrophy protein kinase is critical for nuclear envelope integrity. J Biol Chem. 2011 Nov 18;286(46):40296-306
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89