Sequence Detail

ID/Version

P53986 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Monocarboxylate transporter 1; Short=MCT 1;AltName: Full=Solute carrier family 16 member 1;

Provider

SWISS-PROT

Sequence

Polypeptide 493 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc16a1	solute carrier family 16 (monocarboxylic acid transporters), member 1	88	110	4	19

Sequence references in MGI

J:31880 Carpenter L, et al., Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettre tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function. Biochim Biophys Acta. 1996 Mar 13;1279(2):157-63
J:49739 Koehler-Stec EM, et al., Monocarboxylate transporter expression in mouse brain. Am J Physiol. 1998 Sep;275(3 Pt 1):E516-24
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:187362 Munton RP, et al., Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics. 2007 Feb;6(2):283-93
J:192583 Pullen TJ, et al., Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic beta-cells leads to relative hyperinsulinism during exercise. Diabetes. 2012 Jul;61(7):1719-25
J:205481 Lengacher S, et al., Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice. PLoS One. 2013;8(12):e82505
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:296826 Reddy A, et al., pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise. Cell. 2020 Oct 1;183(1):62-75.e17
J:326231 Mannowetz N, et al., Basigin interacts with both MCT1 and MCT2 in murine spermatozoa. J Cell Physiol. 2012 May;227(5):2154-62