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Sequence Detail
ID/Version
P53690 O08645 Q8BTX2 O35369 (UniProt | EBI) Last sequence update: 2011-07-27
Last annotation update: 2014-07-09
Sequence
description
from provider
RecName: Full=Matrix metalloproteinase-14; Short=MMP-14; EC=3.4.24.80;AltName: Full=MMP-X1;AltName: Full=MT-MMP;AltName: Full=Membrane-type matrix metalloproteinase 1; Short=MT-MMP 1; Short=MTMMP1;AltName: Full=Membrane-typ
Provider SWISS-PROT
Sequence
Polypeptide 582 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Mmp14 matrix metallopeptidase 14 (membrane-inserted) 36 6 5 17
Sequence references in MGI J:32782 Okada A, et al., Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2730-4
J:43437 Apte SS, et al., The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis. J Biol Chem. 1997 Oct 10;272(41):25511-7
J:48622 Ota K, et al., Cloning of murine membrane-type-1-matrix metalloproteinase (MT-1-MMP) and its metanephric developmental regulation with respect to MMP-2 and its inhibitor. Kidney Int. 1998 Jul;54(1):131-42
J:57969 Holmbeck K, et al., MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell. 1999 Oct 1;99(1):81-92
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:110103 Rozanov DV, et al., Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice. Cancer Res. 2006 Jun 15;66(12):6258-63

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory