Sequence Detail

ID/Version

P53668 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=LIM domain kinase 1; Short=LIMK-1; EC=2.7.11.1 {ECO:0000250|UniProtKB:P53667};AltName: Full=KIZ-1;

Provider

SWISS-PROT

Sequence

Polypeptide 647 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Limk1	LIM domain kinase 1	66	122	4	10

Sequence references in MGI

J:28711 Cheng AK, et al., The murine LIM-kinase gene (limk) encodes a novel serine threonine kinase expressed predominantly in trophoblast giant cells and the developing nervous system. Mech Dev. 1995 Aug;52(2-3):187-97
J:29439 Proschel C, et al., Limk1 is predominantly expressed in neural tissues and phosphorylates serine, threonine and tyrosine residues in vitro. Oncogene. 1995 Oct 5;11(7):1271-81
J:37753 Bernard O, et al., Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons. Cell Growth Differ. 1994 Nov;5(11):1159-71
J:64707 Martindale DW, et al., Comparative genomic sequence analysis of the williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Mamm Genome. 2000 Oct;11(10):890-8
J:101335 Tursun B, et al., The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones. Genes Dev. 2005 Oct 1;19(19):2307-19
J:137325 Ding Y, et al., Nischarin inhibits LIM kinase to regulate cofilin phosphorylation and cell invasion. Mol Cell Biol. 2008 Jun;28(11):3742-56
J:243478 Lee IC, et al., Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. J Biol Chem. 2014 Sep 26;289(39):26989-7003
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89