Sequence Detail

ID/Version

P53368 Q8VDG0 Q542J4 P97795 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Oxidized purine nucleoside triphosphate hydrolase {ECO:0000305}; EC=3.6.1.56 {ECO:0000250|UniProtKB:P36639};AltName: Full=2-hydroxy-dATP diphosphatase;AltName: Full=7,8-dihydro-8-oxoguanine triphosphatase;AltName: Full=8-oxo-dGTPase;

Provider

SWISS-PROT

Sequence

Polypeptide 156 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nudt1	nudix hydrolase 1	66	96	3	54

Sequence references in MGI

J:29544 Kakuma T, et al., Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution. J Biol Chem. 1995 Oct 27;270(43):25942-8
J:38676 Igarashi H, et al., Organization and expression of the mouse MTH1 gene for preventing transversion mutation. J Biol Chem. 1997 Feb 7;272(6):3766-72
J:71836 Tsuzuki T, et al., Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11456-61
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:286825 Scaletti ER, et al., MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool. J Biol Chem. 2020 Apr 10;295(15):4761-4772
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89