Sequence Detail

ID/Version

P53349 Q9R0U3 Q9R256 Q60831 (UniProt | EBI)

Last sequence update: 2001-09-26
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Mitogen-activated protein kinase kinase kinase 1; EC=2.7.11.25;AltName: Full=MAPK/ERK kinase kinase 1; Short=MEK kinase 1; Short=MEKK 1;

Provider

SWISS-PROT

Sequence

Polypeptide 1493 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Map3k1	mitogen-activated protein kinase kinase kinase 1	58	105	3	17

Sequence references in MGI

J:29891 Lange-Carter CA, et al., A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science. 1993 Apr 16;260(5106):315-9
J:64817 Ito M, et al., JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. Mol Cell Biol. 1999 Nov;19(11):7539-48
J:114128 Tu Z, et al., Subdomain VIII is a specificity-determining region in MEKK1. J Biol Chem. 2003 Nov 28;278(48):48498-505
J:126838 Ye B, et al., GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway. FEBS Lett. 2007 Sep 18;581(23):4403-10
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:231212 Deak JC, et al., Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain. Biochem J. 1997 Feb 15;322 ( Pt 1):185-92
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89