Sequence Detail

ID/Version

P51954 (UniProt | EBI)

Last sequence update: 2006-01-10
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase Nek1; EC=2.7.11.1 {ECO:0000269|PubMed:1382974};AltName: Full=Never in mitosis A-related kinase 1; Short=NimA-related protein kinase 1;

Provider

SWISS-PROT

Sequence

Polypeptide 1203 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nek1	NIMA (never in mitosis gene a)-related expressed kinase 1	42	105	3	13

Sequence references in MGI

J:2376 Letwin K, et al., A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. EMBO J. 1992 Oct;11(10):3521-31
J:79192 Feige E, et al., Nurit, a novel leucine-zipper protein, expressed uniquely in the spermatid flower-like structure. Mech Dev. 2002 Sep;117(1-2):369
J:175359 Mahjoub MR, et al., NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes. J Am Soc Nephrol. 2005 Dec;16(12):3485-9
J:219092 Chen Y, et al., Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control. Cell Cycle. 2008 Oct;7(20):3194-201
J:241518 Sonntag T, et al., Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members. PLoS One. 2017;12(2):e0173013
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89