Sequence Detail

ID/Version

P51791 Q8K4X0 Q8K4X1 Q3TF45 (UniProt | EBI)

Last sequence update: 2020-08-12
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=H(+)/Cl(-) exchange transporter 3;AltName: Full=Chloride channel protein 3; Short=ClC-3;AltName: Full=Chloride transporter ClC-3;

Provider

SWISS-PROT

Sequence

Polypeptide 818 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Clcn3	chloride channel, voltage-sensitive 3	92	106	3	88

Sequence references in MGI

J:25621 Borsani G, et al., Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein. Genomics. 1995 May 1;27(1):131-41
J:96150 Hara-Chikuma M, et al., ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation. J Biol Chem. 2005 Jan 14;280(2):1241-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:141089 Maritzen T, et al., Role of the vesicular chloride transporter ClC-3 in neuroendocrine tissue. J Neurosci. 2008 Oct 15;28(42):10587-98
J:287033 Guzman RE, et al., Preferential association with ClC-3 permits sorting of ClC-4 into endosomal compartments. J Biol Chem. 2017 Nov 17;292(46):19055-19065
J:287043 Suzuki T, et al., Intracellular localization of ClC chloride channels and their ability to form hetero-oligomers. J Cell Physiol. 2006 Mar;206(3):792-8
J:287048 Okada T, et al., A newly cloned ClC-3 isoform, ClC-3d, as well as ClC-3a mediates Cd-sensitive outwardly rectifying anion currents. Cell Physiol Biochem. 2014;33(3):539-56
J:287052 Guzman RE, et al., Neuronal ClC-3 Splice Variants Differ in Subcellular Localizations, but Mediate Identical Transport Functions. J Biol Chem. 2015 Oct 23;290(43):25851-62