Sequence Detail

ID/Version

P51683 Q61172 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=C-C chemokine receptor type 2; Short=C-C CKR-2; Short=CC-CKR-2; Short=CCR-2; Short=CCR2;AltName: Full=JE/FIC receptor;AltName: Full=MCP-1 receptor;AltName: CD_antigen=CD192;

Provider

SWISS-PROT

Sequence

Polypeptide 373 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ccr2	C-C motif chemokine receptor 2	116	99	7	27

Sequence references in MGI

J:32263 Boring L, et al., Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9. J Biol Chem. 1996 Mar 29;271(13):7551-8
J:33019 Kurihara T, et al., Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC. J Biol Chem. 1996 May 17;271(20):11603-7
J:37573 Sarafi MN, et al., Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med. 1997 Jan 6;185(1):99-109
J:247722 Bakos E, et al., CCR2 Regulates the Immune Response by Modulating the Interconversion and Function of Effector and Regulatory T Cells. J Immunol. 2017 Jun 15;198(12):4659-4671
J:261392 Frik J, et al., Cross-talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury. EMBO Rep. 2018 May;19(5)
J:269556 Hsieh CL, et al., CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury. J Neurotrauma. 2014 Oct 15;31(20):1677-88
J:269563 Aili A, et al., CCR2 Signal Facilitates Thymic Egress by Priming Thymocyte Responses to Sphingosine-1-Phosphate. Front Immunol. 2018;9:1263
J:269680 Wu XB, et al., Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell. Neuropsychopharmacology. 2018 Oct;43(11):2320-2330