Sequence Detail

ID/Version

P51667 Q6P8P4 Q9QVP3 (UniProt | EBI)

Last sequence update: 2007-04-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Myosin regulatory light chain 2, ventricular/cardiac muscle isoform {ECO:0000305}; Short=MLC-2 {ECO:0000303|PubMed:1379240}; Short=MLC-2v;AltName: Full=Myosin light chain 2, slow skeletal/ventricular muscle isoform {ECO:00002

Provider

SWISS-PROT

Sequence

Polypeptide 166 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	43	195	4	45

Sequence references in MGI

J:12566 O'Brien TX, et al., Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5157-61
J:19811 Lee KJ, et al., Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene. J Biol Chem. 1992 Aug 5;267(22):15875-85
J:45125 Chen J, et al., Selective requirement of myosin light chain 2v in embryonic heart function. J Biol Chem. 1998 Jan 9;273(2):1252-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114298 Sanbe A, et al., Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2. J Biol Chem. 1999 Jul 23;274(30):21085-94
J:159890 Chang AN, et al., Cardiac myosin is a substrate for zipper-interacting protein kinase (ZIPK). J Biol Chem. 2010 Feb 19;285(8):5122-6
J:163318 Schaner Tooley CE, et al., NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. Nature. 2010 Jul 28;466(7310):1125-1128
J:184548 Sheikh F, et al., Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest. 2012 Apr 2;122(4):1209-21
J:210147 Warren SA, et al., Myosin light chain phosphorylation is critical for adaptation to cardiac stress. Circulation. 2012 Nov 27;126(22):2575-88
J:224740 Stelzer JE, et al., Acceleration of stretch activation in murine myocardium due to phosphorylation of myosin regulatory light chain. J Gen Physiol. 2006 Sep;128(3):261-72
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89