Sequence Detail

ID/Version

P51448 P97773 P70283 Q923G1 P97741 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nuclear receptor ROR-alpha;AltName: Full=Nuclear receptor RZR-alpha;AltName: Full=Nuclear receptor subfamily 1 group F member 1;AltName: Full=RAR-related orphan receptor A;AltName: Full=Retinoid-related orphan receptor-alpha;

Provider

SWISS-PROT

Sequence

Polypeptide 523 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rora	RAR-related orphan receptor alpha	119	142	4	28

Sequence references in MGI

J:18923 Carlberg C, et al., RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. Mol Endocrinol. 1994 Jun;8(6):757-70
J:29395 Matsui T, et al., An orphan nuclear receptor, mROR alpha, and its spatial expression in adult mouse brain. Brain Res Mol Brain Res. 1995 Nov;33(2):217-26
J:31470 Hamilton BA, et al., Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature. 1996 Feb 22;379(6567):736-9
J:41653 Matysiak-Scholze U, et al., The structural integrity of ROR alpha isoforms is mutated in staggerer mice: cerebellar coexpression of ROR alpha1 and ROR alpha4. Genomics. 1997 Jul 1;43(1):78-84
J:87181 Gold DA, et al., RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron. 2003 Dec 18;40(6):1119-31
J:122764 Liu C, et al., Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature. 2007 May 24;447(7143):477-81
J:124837 Raspe E, et al., Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha. J Biol Chem. 2001 Jan 26;276(4):2865-71
J:131020 Yang XO, et al., T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity. 2008 Jan;28(1):29-39
J:138180 Lau P, et al., The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity. J Biol Chem. 2008 Jun 27;283(26):18411-21
J:142097 Chopra AR, et al., Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science. 2008 Nov 28;322(5906):1395-9
J:143073 Fujieda H, et al., Retinoic acid receptor-related orphan receptor alpha regulates a subset of cone genes during mouse retinal development. J Neurochem. 2009 Jan;108(1):91-101
J:148702 Ohoka N, et al., The orphan nuclear receptor ROR{alpha} restrains adipocyte differentiation through a reduction of C/EBP{beta} activity and perilipin gene expression. Mol Endocrinol. 2009 Jun;23(6):759-71
J:156994 Schmutz I, et al., The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev. 2010 Feb 15;24(4):345-57
J:179376 Lamia KA, et al., Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature. 2011 Dec 22;480(7378):552-6
J:199687 Takeda Y, et al., RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo. Nucleic Acids Res. 2012 Sep 1;40(17):8519-35
J:200375 Wang X, et al., Interaction of MAGED1 with nuclear receptors affects circadian clock function. EMBO J. 2010 Apr 21;29(8):1389-400
J:205671 Wang Y, et al., Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands. J Biol Chem. 2010 Feb 12;285(7):5013-25
J:206917 Wada T, et al., Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol. 2008 Mar;73(3):891-9
J:207076 Kang HS, et al., Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism. Physiol Genomics. 2007 Oct 22;31(2):281-94
J:209475 Saito T, et al., Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility. Circulation. 2013 Jan 1;127(1):104-14
J:213087 Takeda Y, et al., Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors alpha- and gamma-mediated transactivation. Nucleic Acids Res. 2013 Aug;41(14):6992-7008
J:213898 Poliandri AH, et al., Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140). J Biol Rhythms. 2011 Jun;26(3):187-99