Sequence Detail

ID/Version

P51141 Q60868 Q3U2D3 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Segment polarity protein dishevelled homolog DVL-1; Short=Dishevelled-1;AltName: Full=DSH homolog 1;

Provider

SWISS-PROT

Sequence

Polypeptide 695 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dvl1	dishevelled segment polarity protein 1	162	115	5	9

Sequence references in MGI

J:21483 Sussman DJ, et al., Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. Dev Biol. 1994 Nov;166(1):73-86
J:30455 Lijam N, et al., Organization and promoter analysis of the mouse dishevelled-1 gene. Genome Res. 1995 Sep;5(2):116-24
J:42758 Lijam N, et al., Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. Cell. 1997 Sep 5;90(5):895-905
J:78399 Luo ZG, et al., Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. Neuron. 2002 Aug 1;35(3):489-505
J:93897 Lu W, et al., Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell. 2004 Oct 1;119(1):97-108
J:95171 Torban E, et al., Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. J Biol Chem. 2004 Dec 10;279(50):52703-13
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:172954 Lee HJ, et al., Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled. Angew Chem Int Ed Engl. 2009;48(35):6448-52
J:175197 Wong HC, et al., Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell. 2003 Nov;12(5):1251-60
J:175318 Liu YT, et al., Molecular basis of Wnt activation via the DIX domain protein Ccd1. J Biol Chem. 2011 Mar 11;286(10):8597-608
J:236814 Kim S, et al., The polycystin complex mediates Wnt/Ca(2+) signalling. Nat Cell Biol. 2016 Jul;18(7):752-64