Sequence Detail

ID/Version

P49615 (UniProt | EBI)

Last sequence update: 1996-02-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cyclin-dependent kinase 5 {ECO:0000312|MGI:MGI:101765}; EC=2.7.11.1;AltName: Full=Cell division protein kinase 5 {ECO:0000305};AltName: Full=Cyclin-dependent-like kinase 5;AltName: Full=Serine/threonine-protein kinase PSSALRE {ECO:00

Provider

SWISS-PROT

Sequence

Polypeptide 292 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cdk5	cyclin dependent kinase 5	212	129	3	18

Sequence references in MGI

J:4073 Ershler M, et al., Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. Gene. 1993 Feb 28;124(2):305-6
J:20997 Ino H, et al., Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems. Brain Res. 1994 Oct 24;661(1-2):196-206
J:28413 Ohshima T, et al., Molecular cloning and chromosomal mapping of the mouse cyclin-dependent kinase 5 gene. Genomics. 1995 Aug 10;28(3):585-8
J:63117 Zukerberg LR, et al., Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron. 2000 Jun;26(3):633-46
J:67864 Ohshima T, et al., Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2764-9
J:71181 Ko J, et al., p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci. 2001 Sep 1;21(17):6758-71
J:76235 Sato H, et al., ik3-2, a relative to ik3-1/Cables, is associated with cdk3, cdk5, and c-abl. Biochim Biophys Acta. 2002 Mar 19;1574(2):157-63
J:85235 Xie Z, et al., Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell. 2003 Aug 22;114(4):469-82
J:102479 Fu AK, et al., Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15224-9
J:117343 Fu WY, et al., Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci. 2007 Jan;10(1):67-76
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:215912 Jacobshagen M, et al., The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism. Development. 2014 Sep;141(17):3370-7
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:284799 He X, et al., Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice. Neurochem Res. 2011 Jul;36(7):1293-303
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89