Sequence Detail

ID/Version

P49138 Q6P561 (UniProt | EBI)

Last sequence update: 2005-01-04
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=MAP kinase-activated protein kinase 2; Short=MAPK-activated protein kinase 2; Short=MAPKAP kinase 2; Short=MAPKAP-K2; Short=MAPKAPK-2; Short=MK-2; Short=MK2; EC=2.7.11.1;

Provider

SWISS-PROT

Sequence

Polypeptide 386 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mapkapk2	MAP kinase-activated protein kinase 2	76	100	4	17

Sequence references in MGI

J:20645 Engel K, et al., The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain. FEBS Lett. 1993 Dec 20;336(1):143-7
J:59678 Kotlyarov A, et al., MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis [see comments]. Nat Cell Biol. 1999 Jun;1(2):94-7
J:112157 Kotlyarov A, et al., Distinct cellular functions of MK2. Mol Cell Biol. 2002 Jul;22(13):4827-35
J:117668 Ronkina N, et al., The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol Cell Biol. 2007 Jan;27(1):170-81
J:126340 Zaru R, et al., The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol. 2007 Nov;8(11):1227-35
J:166791 Menon MB, et al., p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins. J Biol Chem. 2010 Oct 22;285(43):33242-51
J:180488 Rousseau S, et al., Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. EMBO J. 2002 Dec 2;21(23):6505-14
J:180499 Engel K, et al., Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation. EMBO J. 1998 Jun 15;17(12):3363-71
J:182396 Eyers CE, et al., The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Biochem J. 2005 Jul 1;389(Pt 1):127-35
J:200320 Chrestensen CA, et al., MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding. J Biol Chem. 2004 Mar 12;279(11):10176-84
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89