Sequence Detail

ID/Version

P49117 P55093 (UniProt | EBI)

Last sequence update: 1996-02-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Nuclear receptor subfamily 2 group C member 2;AltName: Full=Orphan nuclear receptor TAK1;AltName: Full=Orphan nuclear receptor TR4;AltName: Full=Testicular receptor 4;

Provider

SWISS-PROT

Sequence

Polypeptide 596 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nr2c2	nuclear receptor subfamily 2, group C, member 2	27	111	3	46

Sequence references in MGI

J:29204 Hirose T, et al., Cloning of the gene encoding the murine orphan receptor TAK1 and cell-type-specific expression in testis. Gene. 1995 Oct 3;163(2):239-42
J:31202 Law SW, et al., Molecular cloning of a novel member of the nuclear receptor superfamily related to the orphan receptor, TR2. Gene Expr. 1994;4(1-2):77-84
J:91602 Mu X, et al., Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis. Mol Cell Biol. 2004 Jul;24(13):5887-99
J:125724 Chen YT, et al., Abnormal cerebellar cytoarchitecture and impaired inhibitory signaling in adult mice lacking TR4 orphan nuclear receptor. Brain Res. 2007 Sep 7;1168:72-82
J:126307 Tanabe O, et al., The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. Genes Dev. 2007 Nov 1;21(21):2832-44
J:151809 Shyr CR, et al., Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells. Endocrinology. 2009 May;150(5):2454-62
J:175342 Kim YS, et al., Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia. Cerebellum. 2010 Sep;9(3):310-23
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30