Sequence Detail

ID/Version

P48999 Q3TB75 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Polyunsaturated fatty acid 5-lipoxygenase {ECO:0000305}; EC=1.13.11.- {ECO:0000250|UniProtKB:P09917};AltName: Full=Arachidonate 5-lipoxygenase; Short=5-LO {ECO:0000250|UniProtKB:P09917}; Short=5-lipoxygenase {ECO:0000

Provider

SWISS-PROT

Sequence

Polypeptide 674 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Alox5	arachidonate 5-lipoxygenase	108	101	3	13

Sequence references in MGI

J:21372 Chen XS, et al., Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature. 1994 Nov 10;372(6502):179-82
J:27425 Chen XS, et al., cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase. J Biol Chem. 1995 Jul 28;270(30):17993-9
J:68714 Goulet JL, et al., Altered inflammatory responses in leukotriene-deficient mice. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12852-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:122095 Doepping S, et al., Selective 5-lipoxygenase expression in Langerhans cells and impaired dendritic cell migration in 5-LO-deficient mice reveal leukotriene action in skin. J Invest Dermatol. 2007 Jul;127(7):1692-700
J:137920 Mehrabian M, et al., Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia. 2008 Jun;51(6):978-88
J:168089 Nagashima T, et al., Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help. Am J Pathol. 2011 Jan;178(1):222-32
J:171000 Sapieha P, et al., 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of omega-3 polyunsaturated fatty acids. Sci Transl Med. 2011 Feb 9;3(69):69ra12
J:206711 Hofheinz K, et al., Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants. Arch Biochem Biophys. 2013 Feb 1;530(1):40-7
J:208193 Brogliato AR, et al., Critical role of 5-lipoxygenase and heme oxygenase-1 in wound healing. J Invest Dermatol. 2014 May;134(5):1436-45
J:219262 Lee SJ, et al., 5-Lipoxygenase plays a pivotal role in endothelial adhesion of monocytes via an increased expression of Mac-1. Cardiovasc Res. 2013 Sep 1;99(4):724-33
J:253033 Kwak HJ, et al., 5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes. Sci Rep. 2017 Jul 10;7(1):5025
J:284986 Guimaraes FR, et al., The inhibition of 5-Lipoxygenase (5-LO) products leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves cutaneous wound healing. Clin Immunol. 2018 May;190:74-83
J:284993 Marbach-Breitruck E, et al., Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme. Antioxid Redox Signal. 2020 Jan 1;32(1):1-17
J:285027 Wu Y, et al., Deletion of Alox5 gene decreases osteogenic differentiation but increases adipogenic differentiation of mouse induced pluripotent stem cells. Cell Tissue Res. 2014 Oct;358(1):135-47
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89