Sequence Detail

ID/Version

P48760 Q3U0B4 A2AK69 Q99K38 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Folylpolyglutamate synthase, mitochondrial; EC=6.3.2.17;AltName: Full=Folylpoly-gamma-glutamate synthetase; Short=FPGS;AltName: Full=Tetrahydrofolylpolyglutamate synthase; Short=Tetrahydrofolate synthase;Flags: Precur

Provider

SWISS-PROT

Sequence

Polypeptide 587 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fpgs	folylpolyglutamyl synthetase	47	98	3	8

Sequence references in MGI

J:31307 Spinella MJ, et al., Molecular cloning of murine folylpoly-gamma-glutamate synthetase. Biochim Biophys Acta. 1996 Feb 7;1305(1-2):11-4
J:31712 Roy K, et al., Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription. J Biol Chem. 1995 Nov 10;270(45):26918-22
J:35630 Roy K, et al., Organization and alternate splicing of the murine folylpolyglutamate synthetase gene. Different splice variants in L1210 cells encode mitochondrial or cytosolic forms of the enzyme. J Biol Chem. 1996 Sep 27;271(39):23820-7
J:38805 Roy K, et al., Additional organizational features of the murine folylpolyglutamate synthetase gene. Two remotely situated exons encoding an alternate 5' end and proximal open reading frame under the control of a second promoter. J Biol Chem. 1997 Feb 28;272(9):5587-93
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:141563 Racanelli AC, et al., A mouse gene that coordinates epigenetic controls and transcriptional interference to achieve tissue-specific expression. Mol Cell Biol. 2008 Jan;28(2):836-48
J:359367 Andreassi JL 2nd, et al., Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors. Biochemistry. 2002 Jan 8;41(1):226-35