Sequence Detail

ID/Version

P48754 Q60983 A2A4Q4 Q60957 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Breast cancer type 1 susceptibility protein homolog; EC=2.3.2.27 {ECO:0000250|UniProtKB:P38398};AltName: Full=RING-type E3 ubiquitin transferase BRCA1 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 1812 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Brca1	breast cancer 1, early onset	130	136	2	93

Sequence references in MGI

J:28391 Marquis ST, et al., The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. Nat Genet. 1995 Sep;11(1):17-26
J:29358 Bennett LM, et al., Isolation of the mouse homologue of BRCA1 and genetic mapping to mouse chromosome 11. Genomics. 1995 Oct 10;29(3):576-81
J:29684 Lane TF, et al., Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes Dev. 1995 Nov 1;9(21):2712-22
J:30135 Abel KJ, et al., Mouse Brca1: localization sequence analysis and identification of evolutionary conserved domains. Hum Mol Genet. 1995 Dec;4(12):2265-73
J:30136 Sharan SK, et al., Murine Brca1: sequence and significance for human missense mutations. Hum Mol Genet. 1995 Dec;4(12):2275-8
J:31275 Schrock E, et al., The murine homolog of the human breast and ovarian cancer susceptibility gene Brca1 maps to mouse chromosome 11D. Hum Genet. 1996 Feb;97(2):256-9
J:183982 Wojtasz L, et al., Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms. Genes Dev. 2012 May 1;26(9):958-73
J:192634 Kogo H, et al., HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Genes Cells. 2012 Nov;17(11):897-912
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89