Sequence Detail

ID/Version

P48432 (UniProt | EBI)

Last sequence update: 1999-07-15
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Transcription factor SOX-2;

Provider

SWISS-PROT

Sequence

Polypeptide 319 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sox2	SRY (sex determining region Y)-box 2	167	448	3	48

Sequence references in MGI

J:29675 Yuan H, et al., Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev. 1995 Nov 1;9(21):2635-45
J:31475 Collignon J, et al., A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development. 1996 Feb;122(2):509-20
J:100846 Maruyama M, et al., Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem. 2005 Jul 1;280(26):24371-9
J:116485 Tsuruzoe S, et al., Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem Biophys Res Commun. 2006 Dec 29;351(4):920-6
J:128002 Rizzoti K, et al., SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis. Development. 2007 Oct;134(19):3437-48
J:161094 Yu HB, et al., Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. J Biol Chem. 2009 Nov 6;284(45):31327-35
J:180508 Andreu-Agullo C, et al., Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Nature. 2012 Jan 12;481(7380):195-8
J:288268 Miwa T, et al., Tsukushi is essential for the development of the inner ear. Mol Brain. 2020 Mar 3;13(1):29
J:297664 Simonson L, et al., Keratin 13 deficiency causes white sponge nevus in mice. Dev Biol. 2020 Dec 1;468(1-2):146-153
J:331350 Zhang C, et al., Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase. J Biol Chem. 2019 Jan 11;294(2):476-489