Sequence Detail

ID/Version

P47809 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4; Short=MAP kinase kinase 4; Short=MAPKK 4; EC=2.7.12.2;AltName: Full=C-JUN N-terminal kinase kinase 1; Short=JNK kinase 1; Short=JNKK 1;AltNam

Provider

SWISS-PROT

Sequence

Polypeptide 397 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Map2k4	mitogen-activated protein kinase kinase 4	34	107	4	19

Sequence references in MGI

J:35302 Sanchez I, et al., Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature. 1994 Dec 22-29;372(6508):794-8
J:52243 Tournier C, et al., The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases. Mol Cell Biol. 1999 Feb;19(2):1569-81
J:53983 Lee JK, et al., Dynamic expression of SEK1 suggests multiple roles of the gene during embryogenesis and in adult brain of mice. Brain Res Mol Brain Res. 1999 Mar 20;66(1-2):133-40
J:77851 Swat W, et al., SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity. 1998 May;8(5):625-34
J:83279 Kishimoto H, et al., Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem. 2003 May 9;278(19):16595-601
J:129038 Wang X, et al., Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol. 2007 Nov;27(22):7935-46
J:165016 Lee CM, et al., JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14189-94
J:223132 Liu W, et al., Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth. Circ Res. 2009 Apr 10;104(7):905-14
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87