Sequence Detail

ID/Version

P47746 Q5SF33 (UniProt | EBI)

Last sequence update: 1996-02-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cannabinoid receptor 1; Short=CB-R; Short=CB1;AltName: Full=Brain-type cannabinoid receptor;

Provider

SWISS-PROT

Sequence

Polypeptide 473 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cnr1	cannabinoid receptor 1	84	117	3	32

Sequence references in MGI

J:30003 Chakrabarti A, et al., Cloning and sequencing of a cDNA encoding the mouse brain-type cannabinoid receptor protein. DNA Seq. 1995;5(6):385-8
J:52188 Ledent C, et al., Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science. 1999 Jan 15;283(5400):401-4
J:98030 McCaw EA, et al., Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice. Eur J Biochem. 2004 Dec;271(23-24):4909-20
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:191260 Benard G, et al., Mitochondrial CB(1) receptors regulate neuronal energy metabolism. Nat Neurosci. 2012 Apr;15(4):558-64
J:202039 Jourdan T, et al., Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat Med. 2013 Sep;19(9):1132-40
J:219854 Koch M, et al., Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature. 2015 Mar 5;519(7541):45-50
J:240242 Hebert-Chatelain E, et al., A cannabinoid link between mitochondria and memory. Nature. 2016 Nov 24;539(7630):555-559
J:240243 Mendizabal-Zubiaga J, et al., Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration. Front Physiol. 2016;7:476
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89