Sequence Detail

ID/Version

P46938 Q91WL1 Q52KJ5 (UniProt | EBI)

Last sequence update: 2010-04-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transcriptional coactivator YAP1; Short=Yes-associated protein 1;AltName: Full=Protein yorkie homolog;AltName: Full=Yes-associated protein YAP65 homolog;

Provider

SWISS-PROT

Sequence

Polypeptide 488 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Yap1	yes-associated protein 1	186	170	3	60

Sequence references in MGI

J:26090 Sudol M, et al., Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem. 1995 Jun 16;270(24):14733-41
J:28324 Chen HI, et al., The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7819-23
J:44866 Ermekova KS, et al., The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. J Biol Chem. 1997 Dec 26;272(52):32869-77
J:167202 Zhao B, et al., Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev. 2011 Jan 1;25(1):51-63
J:169049 Varelas X, et al., The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. Dev Cell. 2010 Dec 14;19(6):831-44
J:227879 Williamson KA, et al., Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects. Am J Hum Genet. 2014 Feb 6;94(2):295-302
J:238700 Kwan J, et al., DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Genes Dev. 2016 Dec 15;30(24):2696-2709
J:260802 Zhou B, et al., Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018 Mar 1;128(3):970-984
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89